Vaccine Boosters

Dr Norman Swan says over-50s should get AstraZeneca now + Pfizer booster at years end. Better protection than 2 Pfizer shots.  25/May/21

  • https://www.youtube.com/watch?v=KMmB3S2xDzg  

  • At 2mins40 into this clip, Norman suggests that Aussie's 50+ will :

    • be better off getting AstraZeneca now plus Pfizer booster at year's end  (He says that is what the Federal Government's policy SHOULD be promising to those Aussies 50+)

Other countries are now starting to use Vaccine Boosters. At 16/8/21, is Australia going to be at the back of the queue in ordering and starting to provide COVID vaccine boosters again?

  • A friend in Thailand told me that Thailand is now (15/Aug/21) giving front-line health workers, the new Pfizer booster.

  • And now we know that Britain (which mainly used AstraZeneca) will be starting to use boosters "next month" .. and I bet those are Pfizer boosters.

  • So now we know that Israel has been testing the new Pfizer booster ... and it works https://twitter.com/EricTopol/status/1425089101926080514   

    • "Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections 1. Vaccines work but their apparent effectiveness is diminished over time + Delta 2. Boosters showing some preliminary evidence of working"

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So let us hope with all their secrecy, the Aussie government has already ordered mRNA boosters for all of us who have received AstraZeneca.  At 17/Aug/21, from this web page       https://www.health.gov.au/initiatives-and-programs/covid-19-vaccines/covid-19-vaccine-government-response/australias-vaccine-agreements   ,  it would seem that Australia has only ordered 15million Moderna boosters - and no other boosters. if that is all that Australia has ordered, that seems to be far too little. So Australia might be at the end of the queue again in ordering boosters .... and so very late again in getting boosters into Australian arms. Not good.

If the Australian government was interested in creating the best health outcome for all Australian's, Australia should be starting to implement Pfizer vaccine boosters NOW for Australian's vaccinated early (or with AstraZeneca)   https://www.puzzlefinancialadvice.com/boosters-for-australia-now-aug-21   

Data showing the rate of decline of effectiveness of Pfizer & AstraZeneca boosters.

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    • 1 more point, since the UK gave @Pfizer at 3-4 wks and 8-12 wks dosing schedules: "The study also suggested that the time between doses did not affect effectiveness in preventing new infections" but unclear if this pertains to Delta infections or overall.

      • https://www.standard.co.uk/news/uk/delta-astrazeneca-pfizer-scientists-oxford-b951340.html   

        • "Sarah Walker, professor of medical statistics and epidemiology at the University of Oxford, said: “We don’t yet know how much transmission can happen from people who get Covid-19 after being vaccinated – for example, they may have high levels of virus for shorter periods of time. But the fact that they can have high levels of virus suggests that people who aren’t yet vaccinated may not be as protected from the Delta variant as we hoped.  This means it is essential for as many people as possible to get vaccinated – both in the UK and worldwide.”

        • Bruce Baker bottom line: Herd immunity is not achievable with Delta variant and current vaccines. So High vaccination levels will not provide protection for the unvaccinated in our community!!!!

25-Aug-21   "Israel’s boosters show signs of taming delta"

25-Aug-21 "COVID vaccine booster shots 'will happen' in Australia, with experts weighing up Delta risk and breakthrough infections"

  • https://www.abc.net.au/news/2021-08-25/pfizer-moderna-covid-vaccine-booster-shots-for-australia/100393856

  • 'Australia has bought 60 million doses of the Pfizer vaccine for 2022 and 25 million doses for 2023, as will as additional supplies of the Moderna vaccine and 51 million doses of Novavax, which is yet to be approved. Health Minister Greg Hunt suggested earlier this month a booster would likely be offered in Australia "12 months" after initial vaccination, but no concrete policy has yet been set. 

  • "[We] won't be in the position to give third doses until everyone has had at least one dose," he said.  

  • Countries with advanced vaccine programs such as Israel have already commenced booster programs via third Pfizer shots to the elderly and health care workers. The booster program came after the country was hit by resurgence of COVID-19, with seven-day average daily case numbers surging past 6,500. Early studies from the program, which kicked off late last month, found protection against infection provided from 10 days after a third dose was four times higher than after two doses.'

2-Aug-21  New focus on vaccine boosters

  • https://www1.racgp.org.au/newsgp/clinical/focus-on-vaccine-boosters-as-israel-becomes-first 

  • Also speaking on Monday, University of Melbourne epidemiologist Tony Blakely said that overseas data suggested booster shots using mRNA vaccines could be particularly effective. He believes a boosting program should be in place in Australia by early next year.  ‘Let’s think ahead a bit more. We want to get everybody fully dosed, or as many people as possible with AstraZeneca or Pfizer,’ he told 3AW.  ‘But then we are going to need to boost. This Delta virus is really quite something. We are going to want to boost first of all those people who have had AstraZeneca and top them up with mRNA, and we are also going to want to vaccinate the children.

  • ‘Those two things would be happening, I hope, early next year so we are in good shape then for opening up to the rest of the world somewhere around March or Easter next year.’

  • In addition to the further Pfizer doses, Australia is expecting 51 million doses of the Novavax vaccine to start arriving by the end of this year. Minister Hunt said last Thursday the Novavax vaccine doses would be ‘ready to be used as a booster as well’.

14-Jul-21 "Novavax | How does Novavax work?"   https://www.youtube.com/watch?v=tlB-5E-wpU0  

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2-Aug-21 "New focus on vaccine boostershttps://www1.racgp.org.au/newsgp/clinical/focus-on-vaccine-boosters-as-israel-becomes-first

  • "However, in a sign of the likely ongoing demand for its vaccine, Pfizer announced last month it had reached a deal to supply a further 200 million further (booster) doses to the US government to be delivered from October this year until April 2022.  

  • The company cited data in its second-quarter teleconference last week which suggests the level of antibodies created by a third (Pfizer booster) dose could be up to the five times the level produced after two doses, and potentially even higher in older patient cohorts.

Doherty Report could grossly underestimate deaths & hospitalisations (and Long-COVID) at 70% & 80% of over-16 year old Aussies vaccinated - More reason to start injecting Pfizer boosters ASAP.  28/Aug/2021

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28-July-21 Pfizer presentation.  https://s21.q4cdn.com/317678438/files/doc_financials/2021/q2/Q2-2021-Earnings-Charts-FINAL.pdf

  • Re Pfizer Booster effectiveness vs Delta:

    • "Initial data shows booster dose of current vaccine (>6 mo. after 2nd dose of BNT162b2) has an overall consistent tolerability profile while eliciting SARS-CoV-2 neutralization titers >5-8X for wild type and 15-21X for Beta variant the range achieved after two primary doses

    • Post dose 3 titers versus the Delta variant are >5-fold post dose 2 titers 18-55 y/o & >11-fold post dose 2 titers 65-85 y/o"

  • "Delta variant vaccine: First batch manufactured; clinical studies projected to begin in Aug. (subject to regulatory approvals)"

24/Aug/21 "Israel's COVID-19 vaccine boosters show signs of taming Delta"

  • https://www.reuters.com/world/middle-east/israels-covid-19-vaccine-boosters-show-signs-taming-delta-2021-08-24/   

  • "More than half of those over 60 have received a third (Pfizer booster) jab, according to the Health ministry.  The rate of new severe cases among unvaccinated patients 70 and older is now seven times that of vaccinated patients, and the gap will continue to grow as long as infections rise, according to Gazit. Among those over 50, that gap is four-fold. "We are optimistic, but very cautious," Israeli Health Minister Nitzan Horowitz told public broadcaster Kan on Sunday. "It gives us more time, slows the spread and we're moving away from lockdown."

22/Aug/21  "Israel finds (Pfizer) COVID-19 vaccine booster significantly lowers infection risk"

  • https://www.reuters.com/world/middle-east/israel-finds-covid-19-vaccine-booster-significantly-lowers-infection-risk-2021-08-22/ 

  • "JERUSALEM, Aug 22 (Reuters) - A third dose of Pfizer (PFE.N)'s COVID-19 vaccine has significantly improved protection from infection and serious illness among people aged 60 and older in Israel compared with those who received two shots, findings published by the Health Ministry showed on Sunday."

  • "Breaking down statistics from Israel's Gertner Institute and KI Institute, ministry officials said that among people aged 60 and over, the protection against infection provided from 10 days after a third dose was four times higher than after two doses. A third jab for over 60-year-olds offered five to six times greater protection after 10 days with regard to serious illness and hospitalisation."

https://www.abc.net.au/news/2021-08-25/pfizer-moderna-covid-vaccine-booster-shots-for-australia/100393856  25/Aug21

  • "Countries with advanced vaccine programs such as Israel have already commenced booster programs via third Pfizer shots to the elderly and health care workers. The booster program came after the country was hit by resurgence of COVID-19 (delta), with seven-day average daily case numbers surging past 6,500. Early studies from the program, which kicked off late last month, found protection against infection provided from 10 days after a third dose was four times higher than after two doses."  

18-Aug-21 Assessment of Boosters by Eric Topol - great summary

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https://twitter.com/EricTopol/status/1438312660974538755   16-Sept-21

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