Moderna Covid vaccine - an mRNA vaccine

The USA has placed their COVID vaccination bets primarily on the 2 mRNA vaccines - Pfizer and Moderna.

Articles of interest.

The USA has relied very heavily on the 2 mRNA vaccines - Pfizer and Moderna.

Anne de Gheest clinical update 16/4/21

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I think Israel in this first round of getting its population almost fully vaccinate, relied almost entire (if not entirely) on Pfizer vaccinations.   https://www.dw.com/en/israels-clever-coronavirus-vaccination-strategy/a-56586888   

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https://time.com/collection/time100-companies/5950001/moderna/

  • "Moderna - Making a new kind of vaccine"  27/Apr/21

    • "The Massachusetts-based biotech company led by CEO Stéphane Bancel went from relative obscurity to the Wall Street spotlight when its mRNA-based COVID-19 vaccine, developed with scientists from the U.S. National Institute of Allergy and Infectious Diseases, became the first in the U.S. to start human testing last March. The vaccine’s December 2020 greenlight by the U.S. Food and Drug Administration—and its subsequent worldwide distribution—vindicates the company’s focus on using mRNA genetic material to teach the human body to fight off COVID-19. Millions have received the shot, and Moderna is ramping up production to meet continued worldwide demand."

The Moderna vaccine order will help but it is not enough.

  • 13/May/21 https://www.theguardian.com/australia-news/2021/may/13/moderna-says-it-has-signed-deal-with-australia-to-supply-25m-doses-of-covid-vaccine 

  • 13/May/21 Australia snaps up 25m doses of Moderna vaccine (afr.com)

    • London | The Morrison government has snapped up 25 million doses of the Moderna vaccine, in a surprise boost to the nation’s COVID-19 vaccination rollout. The deal will deliver 10 million doses of Moderna’s standard vaccine this year and 15 million of its booster vaccine candidate next year, the US-based pharmaceutical giant said late on Wednesday (AEST).

    • The news came after the government announced in the budget that it planned to spend an unspecified amount bankrolling the creation of immediate, large-scale manufacturing capability for mRNA drugs in Australia.

    • Moderna’s vaccine is being used extensively in the US, Britain and Europe. It is made in Europe and the US by Swiss company Lonza.

    • Lonza uses lipids from Germany to make the vaccine, which is then filled and finished in Spain and France. Lonza’s US output has an entirely American supply chain. Its combined trans-Atlantic capacity is at least 700 million doses this year and 1.4 billion next year.

    • It is said to be close to 100 per cent effective against hospitalisation and death, and early research suggests it can protect against the British, South African and Brazilian variants.

    • Novavax CEO Stanley Erck this week said raw materials shortages had forced it to delay the process of getting its vaccine out into the market. The company will no longer seek regulatory approval in the US and Britain by the end of June as previously expected, and is instead targeting the third quarter.

https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-south-korea-sign-production-deal-mrna-vaccines-2021-05-22/  

  • "Moderna, Novavax to produce more COVID-19 vaccines in S.Korea"  23/May/2021

    • "Saturday's agreements with the U.S. drugmakers came a day after U.S. President Joe Biden said that he and South Korean President Moon Jae-in had agreed on a comprehensive partnership on COVID-19 vaccines and that the United States would provide vaccinations for 550,000 South Korean soldiers."

    • "Moderna, whose shot was granted approval in South Korea on Friday, said on Saturday its vaccine will be manufactured by Samsung Biologics Co (207940.KS) and that it intends to supply these vaccines to markets outside the United States starting in the third quarter."

    • South Korea has emerged as a global vaccine production base with its fourth COVID-19 vaccine contract manufacturing deal, Vice Health Minister Kang Do-tae told a briefing on Sunday.

    • "We will continue to explore options for establishing potential local manufacturing opportunities in South Korea," Moderna Chief Executive Stephane Bancel said in a press release.